Functional Ultrastructure: Atlas of Tissue Biology and Pathology

Front Cover
Springer Science & Business Media, Jul 16, 2010 - Science - 366 pages
The period between 1950 and 1980 were the golden unique insights into how pathological processes affect years of transmission electron microscopy and produced cell organization. a plethora of new information on the structure of cells This information is vital to current work in which that was coupled to and followed by biochemical and the emphasis is on integrating approaches from functional studies. TEM was king and each micrograph proteomics, molecular biology, genetics, genomics, of a new object produced new information that led to molecular imaging and physiology and pathology to novel insights on cell and tissue organization and their understand cell functions and derangements in disease. functions. The quality of data represented by the images In this current era, there is a growing tendency to of cell and tissues had been perfected to a very high level substitut e modern light microscopic techniques for by the great microscopists of that era including Palade, electron microscopy, because it is less technically Porter, Fawcett, Sjostrand, Rhodin and many others. At demanding and is more readily available to researchers- present, the images that we see in leading journals for This atlas reminds us that the information obtained by the most part do not reach the same technical level and electron microscopy is invaluable and has no substitute.
 

Contents

STRUCTURAL ORGANISATION OF A MAMMALIAN CELL
2
ARCHITECTURE OF THE CELL NUCLEUS
4
CYTOCHEMICAL DETECTION OF RIBONUCLEOPROTEINS
6
DETECTION OF SITES OF DNA REPLICATION AND OF INTERPHASE CHROMOSOME DOMAINS
8
NUCLEOLUS
10
CHANGES OF THE NUCLEOLAR ARCHITECTURE
12
DETECTION OF SITES OF RNA SYNTHESIS
14
NUCLEAR PORE COMPLEXES
16
GLOMERULAR BASEMENT MEMBRANE
182
DESCEMETS MEMBRANE
184
AN EPITHELCONNECTIVE TISSUE JUNCTIONAL COMPLEX
186
EPIDERMOLYSIS BULLOSA SIMPLEX
188
PRINCIPLES OF TISSUE ORGANISATION
191
PANCREATIC ACINUS
192
ACINAR AND CENTROACINAR CELLS
194
PANCREATIC INTERCALATED DUCT
196

STRUCTURAL CHANGES AS MONITORED BY TIMELAPSE ATOMIC FORCE MICROSCOPY
18
MITOSIS AND CELL DIVISION
20
APOPTOSIS
22
SECRETORY PATHWAY OF PANCREATIC ACINAR CELLS
24
ENDOMEMBRANE SYSTEM OF DINOFLAGELLATES
26
RIBOSOMES ROUGH ENDOPLASMIC RETICULUM
28
NUCLEAR ENVELOPE AND ROUGH ENDOPLASMIC RETICULUM
30
ANNULATE LAMELLAE
32
SITE OF PROTEIN TRANSLOCATION AND INITIATION OF PROTEIN NGLYCOSYLATION
34
OLIGOSACCHARIDE TRIMMING REGLUCOSYLATION AND PROTEIN QUALITY CONTROL IN THE ROUGH ENDOPLASMIC RETICULUM
36
STORAGE SITE OF AGGREGATES OF MISFOLDED GLYCOPROTEINS
38
RUSSELL BODIES AND AGGRESOMES REPRESENT DIFFERENT TYPES OF PROTEIN INCLUSION BODIES
40
SMOOTH ENDOPLASMIC RETICULUM
42
PROLIFERATION OF THE SMOOTH ENDOPLASMIC RETICULUM
44
PREGOLGI INTERMEDIATES
46
OLIGOSACCHARIDE TRIMMING AND PROTEIN QUALITY CONTROL
48
A MAIN CROSSROADS ALONG SECRETORY PATHWAYS
50
PROTEIN SECRETION VISUALISED BY IMMUNOELECTRON MICROSCOPY
52
OLIGOSACCHARIDE TRIMMING IN THE GOLGI APPARATUS AND PREGOLGI INTERMEDIATES
54
SITE OF MATURATION OF ASPARAGINELINKED OLIGOSACCHARIDES
56
CELL TYPERELATED VARIATIONS IN THE TOPOGRAPHY OF GOLGI APPARATUS GLYCOSYLATION REACTIONS
58
CELL TYPERELATED DIFFERENCES IN OLIGOSACCHARIDE STRUCTURE
60
TOPOGRAPHY OF BIOSYNTHESIS OF SERINETHREONINELINKED OLIGOSACCHARIDES
62
GOLGI APPARATUS AND TGN STRUCTURAL CONSIDERATIONS
64
GOLGI APPARATUS AND TGN SECRETION AND ENDOCYTOSIS
66
GOLGI APPARATUS TGN AND TRANS GOLGIER
68
TILT SERIES
70
STRUCTURE OF THE TGN
72
BREFELDIN AINDUCED GOLGI APPARATUS DISASSEMBLY
74
TUBULATION OF GOLGI APPARATUS AND ENDOSOMES
76
EFFECT ON RETROGRADE TRANSPORT OF INTERNALISED WGA
78
TRANSITIONAL ERELEMENTS AND PREGOLGI INTERMEDIATES
80
HEAT SHOCK RESPONSE OF THE GOLGI APPARATUS
82
GOLGI APPARATUS CHANGES UPON ATPDEPLETION AND ATPREPLENISHMENT
84
SECRETORY GRANULES
86
SECRETORY GRANULE TYPES
88
GOBLET CELL COMPOUND EXOCYTOSIS
90
RECEPTORMEDIATED ENDOCYTOSIS VIA CLATHRINCOATED VESICLES AND VIRUS ENDOCYTOSIS
92
ENDOSOMES AND ENDOCYTIC PATHWAYS
94
ENDOCYTIC TRANS GOLGI NETWORK AND RETROGRADE TRAFFIC INTO THE GOLGI APPARATUS
96
TUBULAR PERICENTRIOLAR ENDOSOMES
98
ANTIGEN PRESENTING DENDRITIC CELLS OF THE EPIDERMIS
100
CAVEOLAE
102
FLUIDPHASE ENDOCYTOSIS AND PHAGOCYTOSIS
104
LYSOSOMES
106
LOCALISATION OF ACID PHOSPHATASE LAMP AND POLYLACTOSAMINE
108
ICELL DISEASE
110
GAUCHERS DISEASE
112
FABRYS DISEASE
114
GM2 GANGLIOSIDOSES
116
FARBERS DISEASE
118
WOLMANS DISEASE
120
GLYCOGENOSIS TYPE II
122
LIMITED SELFDIGESTION
124
AUTOPHAGY OF PEROXISOMES
126
CRISTA AND TUBULUS TYPES
128
ABNORMALITIES OF MITOCHONDRIA
130
MULTITALENTED ORGANELLES
132
PEROXISOME BIOGENESIS
134
ADAPTIVE CHANGES
136
PEROXISOMAL DISORDERS
138
GLYCOGEN
140
ERYTHROPOIETIC PROTO PORPHYRIA
142
CYTOCENTRE CENTROSOME AND MICROTUBULES
144
EFFECTS OF MICROTUBULE DISRUPTION
146
ACTIN FILAMENTS
148
INTERMEDIATE FILAMENTS
150
MALLORY BODIES
152
THE PLASMA MEMBRANE
154
CELLS IN CULTURE
156
BRUSH CELL
158
GLYCOCALYX CELL COAT
160
CELL TYPE SPECIFICITY AND DOMAINS
162
GLYCOCALYX CHANGES IN TUMOURS
164
JUNCTIONAL COMPLEX
166
TIGHT JUNCTIONS AND GAP JUNCTIONS
168
TUNNELING NANOTUBES
170
SPOT DESMOSOMES
172
SELECTIN LIGANDMEDIATED CELLCELL INTERACTION
174
CELLULAR INTERDIGITATIONS
176
BASAL LABYRINTH
178
BASEMENT MEMBRANE
180
SUBMANDIBULAR GLAND
198
GOBLET CELLS UNICELLULAR GLANDS
200
SECRETION OF ACID
202
IMPORTANT REGULATORS OF ACIDBASE BALANCE
204
INSULINPRODUCING BETA CELLS OF ISLETS OF LANGERHANS
206
IMPAIRED INSULIN PROCESSING IN HUMAN INSULINOMA
208
CELLS OF THE DISSEMINATED ENDOCRINE SYSTEM
210
LIVER
212
HEPATOCYTES KUPFFER CELL CELL OF ITO
214
BILE CANALICULI
216
PATHWAY OF SECRETORY LIPOPROTEIN PARTICLES
218
CONGENITAL HEPATIC FIBROSIS
220
CHOROID PLEXUS EPENDYMA
222
ABSORPTIVE CELLS
224
PATHWAY OF LIPIDS
226
A REABSORPTION PLANT
228
PARATHYROID HORMONE RESPONSE OF RENAL PROXIMAL TUBULES
230
SIGNALLING OF LIGHT
232
LIGHTINDUCED APOPTOSIS
234
OLFACTORY EPITHELIUM
236
CORNEAL EPITHELIUM
238
EPIDERMIS
240
DIFFERENTIATION OF KERATINOCYTES AND FORMATION OF THE EPIDERMAL FLUID BARRIER
242
THE TRACHEOBRONCHIAL EPITHELIUM
244
IMMOTILE CILIA SYNDROME AND KARTAGENER SYNDROME
246
GAS EXCHANGE AND HOST DEFENSE
248
UMBRELLA CELL SURFACE SPECIALISATIONS
250
UMBRELLA CELL FUSIFORM VESICLES
252
CONTINUOUS CAPILLARY WEIBELPALADE BODIES
254
HYALINE ARTERIOLOSCLEROSIS
256
FENESTRATED CAPILLARY
258
ENDOTHELIOPERICYTE AND ENDOTHELIOSMOOTH MUSCLE CELL INTERACTIONS
260
A SPECIALISED DEVICE FOR FILTERING
262
MINIMAL CHANGE GLOMERULOPATHY AND CONGENITAL NEPHROTIC SYNDROMES
264
MEMBRANOUS GLOMERULONEPHRITIS
266
MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS
268
IgA NEPHROPATHY BERGER
270
CHRONIC ALLOGRAFT GLOMERULOPATHY
272
LOOSE CONNECTIVE TISSUE
274
FIBROBLAST FIBROCYTE MACROPHAGE
276
COLLAGEN AND ELASTIC FIBRES
278
EOSINOPHILIC GRANULOCYTE PLASMA CELL MACROPHAGE MAST CELL
280
COLLAGEN BUNDLES IN THE CORNEA
282
BOWMANS LAYER
284
AMYLOIDOSIS OF KIDNEY
286
GROWTH AS SEEN BY TIME LAPSE ATOMIC FORCE MICROSCOPY
288
WHITE ADIPOSE TISSUE
290
BROWN ADIPOSE TISSUE
292
ARTICULAR CARTILAGE
294
OSTEOBLASTS AND OSTEOCYTES
296
OSTEOCLAST
298
MYOFIBRILS AND SARCOMERE
300
SARCOPLASMIC RETICULUM TRIAD SATELLITE CELL
302
NEUROMUSCULAR JUNCTION
304
MUSCULAR DYSTROPHIES
306
GLYCOGENOSIS TYPE II POMPE
308
MYOFIBRILS INTERCALATED DISK
310
SMOOTH MUSCLE CELLS SYNAPSE A DISTANCE
312
CADASIL
314
NEURON GLIAL CELLS
316
BLOODBRAIN BARRIER SYNAPSES
318
STRUCTURE OF THE SYNAPTIC TERMINAL
320
UNMYELINATED NERVE FIBRE
322
CONNECTIVE TISSUE COMPONENTS
324
MYELINATED NERVE FIBRE MYELIN
326
NODE OF RANVIER
328
AXONAL DEGENERATION
330
NEUROAXONAL DYSTROPHY
332
NEUROPATHIES ASSOCIATED WITH DYSPROTEINAEMIAS
334
METACHROMATIC LEUKODYSTROPHY
336
NEURONAL CEROID L1POFUSCINOSIS
338
RED BLOOD CELLS AND CELLS OF THE ERYTHROID LINEAGE
340
NEUTROPHILIC GRANULOCYTE
342
EOSINOPHILIC GRANULOCYTE
344
BASOPHILIC GRANULOCYTE
346
MONOCYTE
348
LYMPHOCYTE
350
MEGAKARYOCYTE AND THROMBOCYTE
352
THROMBOCYTES
354
SUBJECT INDEX
356
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About the author (2010)

Professor Margit Pavelka, MD. Studies in Medicine, University of Vienna. Medical training at the Vienna Hospital “Rudolfstiftung” and at the Vienna General Hospital. Specialization in Internal Medicine. Resident at the Institute of Micromorphology and Electron Microscopy, Vienna. Specialization in the fields of electron microscopy, cytology, histochemistry, cytochemistry, and ultrastructural histology.Habilitation and University Docent in Histology and Embryology. Professor of Histology and Embryology, University of Innsbruck. Currently Professor of Histology and Embryology, Medical University of Vienna. Main research interests: Morpho-functional organization of the Golgi apparatus; secretory and endocytic pathways; visualization of cellular dynamics; cell traffic in health and disease; cellular stress.

Professor Jürgen Roth, MD, PhD. Studies in Medicine, Friedrich-Schiller-University, Jena. Resident at the Institute of Pathology, Friedrich-Schiller-University, Jena. Habilitation and University Docent in Pathology, Friedrich-Schiller-University, Jena. Research Associate, Department of Morphology, University of Geneva. Associate Professor of Cell Biology, Biozentrum, University of Basel. Professor Emeritus of Cell and Molecular Pathology, University of Zurich. Currently Distinguished Professor, World Class University Programme, Department of Biomedical Science, Yonsei University, Seoul. Main research interests: Topography of protein glycosylation; protein quality control; protein folding diseases; carcinoma-associated glycoconjugates.

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