Functional Ultrastructure: Atlas of Tissue Biology and PathologyThe period between 1950 and 1980 were the golden unique insights into how pathological processes affect years of transmission electron microscopy and produced cell organization. a plethora of new information on the structure of cells This information is vital to current work in which that was coupled to and followed by biochemical and the emphasis is on integrating approaches from functional studies. TEM was king and each micrograph proteomics, molecular biology, genetics, genomics, of a new object produced new information that led to molecular imaging and physiology and pathology to novel insights on cell and tissue organization and their understand cell functions and derangements in disease. functions. The quality of data represented by the images In this current era, there is a growing tendency to of cell and tissues had been perfected to a very high level substitut e modern light microscopic techniques for by the great microscopists of that era including Palade, electron microscopy, because it is less technically Porter, Fawcett, Sjostrand, Rhodin and many others. At demanding and is more readily available to researchers- present, the images that we see in leading journals for This atlas reminds us that the information obtained by the most part do not reach the same technical level and electron microscopy is invaluable and has no substitute. |
Contents
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DETECTION OF SITES OF DNA REPLICATION AND OF INTERPHASE CHROMOSOME DOMAINS | 8 |
NUCLEOLUS | 10 |
CHANGES OF THE NUCLEOLAR ARCHITECTURE | 12 |
DETECTION OF SITES OF RNA SYNTHESIS | 14 |
NUCLEAR PORE COMPLEXES | 16 |
GLOMERULAR BASEMENT MEMBRANE | 182 |
DESCEMETS MEMBRANE | 184 |
AN EPITHELCONNECTIVE TISSUE JUNCTIONAL COMPLEX | 186 |
EPIDERMOLYSIS BULLOSA SIMPLEX | 188 |
PRINCIPLES OF TISSUE ORGANISATION | 191 |
PANCREATIC ACINUS | 192 |
ACINAR AND CENTROACINAR CELLS | 194 |
PANCREATIC INTERCALATED DUCT | 196 |
STRUCTURAL CHANGES AS MONITORED BY TIMELAPSE ATOMIC FORCE MICROSCOPY | 18 |
MITOSIS AND CELL DIVISION | 20 |
APOPTOSIS | 22 |
SECRETORY PATHWAY OF PANCREATIC ACINAR CELLS | 24 |
ENDOMEMBRANE SYSTEM OF DINOFLAGELLATES | 26 |
RIBOSOMES ROUGH ENDOPLASMIC RETICULUM | 28 |
NUCLEAR ENVELOPE AND ROUGH ENDOPLASMIC RETICULUM | 30 |
ANNULATE LAMELLAE | 32 |
SITE OF PROTEIN TRANSLOCATION AND INITIATION OF PROTEIN NGLYCOSYLATION | 34 |
OLIGOSACCHARIDE TRIMMING REGLUCOSYLATION AND PROTEIN QUALITY CONTROL IN THE ROUGH ENDOPLASMIC RETICULUM | 36 |
STORAGE SITE OF AGGREGATES OF MISFOLDED GLYCOPROTEINS | 38 |
RUSSELL BODIES AND AGGRESOMES REPRESENT DIFFERENT TYPES OF PROTEIN INCLUSION BODIES | 40 |
SMOOTH ENDOPLASMIC RETICULUM | 42 |
PROLIFERATION OF THE SMOOTH ENDOPLASMIC RETICULUM | 44 |
PREGOLGI INTERMEDIATES | 46 |
OLIGOSACCHARIDE TRIMMING AND PROTEIN QUALITY CONTROL | 48 |
A MAIN CROSSROADS ALONG SECRETORY PATHWAYS | 50 |
PROTEIN SECRETION VISUALISED BY IMMUNOELECTRON MICROSCOPY | 52 |
OLIGOSACCHARIDE TRIMMING IN THE GOLGI APPARATUS AND PREGOLGI INTERMEDIATES | 54 |
SITE OF MATURATION OF ASPARAGINELINKED OLIGOSACCHARIDES | 56 |
CELL TYPERELATED VARIATIONS IN THE TOPOGRAPHY OF GOLGI APPARATUS GLYCOSYLATION REACTIONS | 58 |
CELL TYPERELATED DIFFERENCES IN OLIGOSACCHARIDE STRUCTURE | 60 |
TOPOGRAPHY OF BIOSYNTHESIS OF SERINETHREONINELINKED OLIGOSACCHARIDES | 62 |
GOLGI APPARATUS AND TGN STRUCTURAL CONSIDERATIONS | 64 |
GOLGI APPARATUS AND TGN SECRETION AND ENDOCYTOSIS | 66 |
GOLGI APPARATUS TGN AND TRANS GOLGIER | 68 |
TILT SERIES | 70 |
STRUCTURE OF THE TGN | 72 |
BREFELDIN AINDUCED GOLGI APPARATUS DISASSEMBLY | 74 |
TUBULATION OF GOLGI APPARATUS AND ENDOSOMES | 76 |
EFFECT ON RETROGRADE TRANSPORT OF INTERNALISED WGA | 78 |
TRANSITIONAL ERELEMENTS AND PREGOLGI INTERMEDIATES | 80 |
HEAT SHOCK RESPONSE OF THE GOLGI APPARATUS | 82 |
GOLGI APPARATUS CHANGES UPON ATPDEPLETION AND ATPREPLENISHMENT | 84 |
SECRETORY GRANULES | 86 |
SECRETORY GRANULE TYPES | 88 |
GOBLET CELL COMPOUND EXOCYTOSIS | 90 |
RECEPTORMEDIATED ENDOCYTOSIS VIA CLATHRINCOATED VESICLES AND VIRUS ENDOCYTOSIS | 92 |
ENDOSOMES AND ENDOCYTIC PATHWAYS | 94 |
ENDOCYTIC TRANS GOLGI NETWORK AND RETROGRADE TRAFFIC INTO THE GOLGI APPARATUS | 96 |
TUBULAR PERICENTRIOLAR ENDOSOMES | 98 |
ANTIGEN PRESENTING DENDRITIC CELLS OF THE EPIDERMIS | 100 |
CAVEOLAE | 102 |
FLUIDPHASE ENDOCYTOSIS AND PHAGOCYTOSIS | 104 |
LYSOSOMES | 106 |
LOCALISATION OF ACID PHOSPHATASE LAMP AND POLYLACTOSAMINE | 108 |
ICELL DISEASE | 110 |
GAUCHERS DISEASE | 112 |
FABRYS DISEASE | 114 |
GM2 GANGLIOSIDOSES | 116 |
FARBERS DISEASE | 118 |
WOLMANS DISEASE | 120 |
GLYCOGENOSIS TYPE II | 122 |
LIMITED SELFDIGESTION | 124 |
AUTOPHAGY OF PEROXISOMES | 126 |
CRISTA AND TUBULUS TYPES | 128 |
ABNORMALITIES OF MITOCHONDRIA | 130 |
MULTITALENTED ORGANELLES | 132 |
PEROXISOME BIOGENESIS | 134 |
ADAPTIVE CHANGES | 136 |
PEROXISOMAL DISORDERS | 138 |
GLYCOGEN | 140 |
ERYTHROPOIETIC PROTO PORPHYRIA | 142 |
CYTOCENTRE CENTROSOME AND MICROTUBULES | 144 |
EFFECTS OF MICROTUBULE DISRUPTION | 146 |
ACTIN FILAMENTS | 148 |
INTERMEDIATE FILAMENTS | 150 |
MALLORY BODIES | 152 |
THE PLASMA MEMBRANE | 154 |
CELLS IN CULTURE | 156 |
BRUSH CELL | 158 |
GLYCOCALYX CELL COAT | 160 |
CELL TYPE SPECIFICITY AND DOMAINS | 162 |
GLYCOCALYX CHANGES IN TUMOURS | 164 |
JUNCTIONAL COMPLEX | 166 |
TIGHT JUNCTIONS AND GAP JUNCTIONS | 168 |
TUNNELING NANOTUBES | 170 |
SPOT DESMOSOMES | 172 |
SELECTIN LIGANDMEDIATED CELLCELL INTERACTION | 174 |
CELLULAR INTERDIGITATIONS | 176 |
BASAL LABYRINTH | 178 |
BASEMENT MEMBRANE | 180 |
SUBMANDIBULAR GLAND | 198 |
GOBLET CELLS UNICELLULAR GLANDS | 200 |
SECRETION OF ACID | 202 |
IMPORTANT REGULATORS OF ACIDBASE BALANCE | 204 |
INSULINPRODUCING BETA CELLS OF ISLETS OF LANGERHANS | 206 |
IMPAIRED INSULIN PROCESSING IN HUMAN INSULINOMA | 208 |
CELLS OF THE DISSEMINATED ENDOCRINE SYSTEM | 210 |
LIVER | 212 |
HEPATOCYTES KUPFFER CELL CELL OF ITO | 214 |
BILE CANALICULI | 216 |
PATHWAY OF SECRETORY LIPOPROTEIN PARTICLES | 218 |
CONGENITAL HEPATIC FIBROSIS | 220 |
CHOROID PLEXUS EPENDYMA | 222 |
ABSORPTIVE CELLS | 224 |
PATHWAY OF LIPIDS | 226 |
A REABSORPTION PLANT | 228 |
PARATHYROID HORMONE RESPONSE OF RENAL PROXIMAL TUBULES | 230 |
SIGNALLING OF LIGHT | 232 |
LIGHTINDUCED APOPTOSIS | 234 |
OLFACTORY EPITHELIUM | 236 |
CORNEAL EPITHELIUM | 238 |
EPIDERMIS | 240 |
DIFFERENTIATION OF KERATINOCYTES AND FORMATION OF THE EPIDERMAL FLUID BARRIER | 242 |
THE TRACHEOBRONCHIAL EPITHELIUM | 244 |
IMMOTILE CILIA SYNDROME AND KARTAGENER SYNDROME | 246 |
GAS EXCHANGE AND HOST DEFENSE | 248 |
UMBRELLA CELL SURFACE SPECIALISATIONS | 250 |
UMBRELLA CELL FUSIFORM VESICLES | 252 |
CONTINUOUS CAPILLARY WEIBELPALADE BODIES | 254 |
HYALINE ARTERIOLOSCLEROSIS | 256 |
FENESTRATED CAPILLARY | 258 |
ENDOTHELIOPERICYTE AND ENDOTHELIOSMOOTH MUSCLE CELL INTERACTIONS | 260 |
A SPECIALISED DEVICE FOR FILTERING | 262 |
MINIMAL CHANGE GLOMERULOPATHY AND CONGENITAL NEPHROTIC SYNDROMES | 264 |
MEMBRANOUS GLOMERULONEPHRITIS | 266 |
MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS | 268 |
IgA NEPHROPATHY BERGER | 270 |
CHRONIC ALLOGRAFT GLOMERULOPATHY | 272 |
LOOSE CONNECTIVE TISSUE | 274 |
FIBROBLAST FIBROCYTE MACROPHAGE | 276 |
COLLAGEN AND ELASTIC FIBRES | 278 |
EOSINOPHILIC GRANULOCYTE PLASMA CELL MACROPHAGE MAST CELL | 280 |
COLLAGEN BUNDLES IN THE CORNEA | 282 |
BOWMANS LAYER | 284 |
AMYLOIDOSIS OF KIDNEY | 286 |
GROWTH AS SEEN BY TIME LAPSE ATOMIC FORCE MICROSCOPY | 288 |
WHITE ADIPOSE TISSUE | 290 |
BROWN ADIPOSE TISSUE | 292 |
ARTICULAR CARTILAGE | 294 |
OSTEOBLASTS AND OSTEOCYTES | 296 |
OSTEOCLAST | 298 |
MYOFIBRILS AND SARCOMERE | 300 |
SARCOPLASMIC RETICULUM TRIAD SATELLITE CELL | 302 |
NEUROMUSCULAR JUNCTION | 304 |
MUSCULAR DYSTROPHIES | 306 |
GLYCOGENOSIS TYPE II POMPE | 308 |
MYOFIBRILS INTERCALATED DISK | 310 |
SMOOTH MUSCLE CELLS SYNAPSE A DISTANCE | 312 |
CADASIL | 314 |
NEURON GLIAL CELLS | 316 |
BLOODBRAIN BARRIER SYNAPSES | 318 |
STRUCTURE OF THE SYNAPTIC TERMINAL | 320 |
UNMYELINATED NERVE FIBRE | 322 |
CONNECTIVE TISSUE COMPONENTS | 324 |
MYELINATED NERVE FIBRE MYELIN | 326 |
NODE OF RANVIER | 328 |
AXONAL DEGENERATION | 330 |
NEUROAXONAL DYSTROPHY | 332 |
NEUROPATHIES ASSOCIATED WITH DYSPROTEINAEMIAS | 334 |
METACHROMATIC LEUKODYSTROPHY | 336 |
NEURONAL CEROID L1POFUSCINOSIS | 338 |
RED BLOOD CELLS AND CELLS OF THE ERYTHROID LINEAGE | 340 |
NEUTROPHILIC GRANULOCYTE | 342 |
EOSINOPHILIC GRANULOCYTE | 344 |
BASOPHILIC GRANULOCYTE | 346 |
MONOCYTE | 348 |
LYMPHOCYTE | 350 |
MEGAKARYOCYTE AND THROMBOCYTE | 352 |
THROMBOCYTES | 354 |
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Other editions - View all
Functional Ultrastructure: Atlas of Tissue Biology and Pathology Margit Pavelka,Jürgen Roth No preview available - 2009 |
Functional Ultrastructure: Atlas of Tissue Biology and Pathology Margit Pavelka,Jürgen Roth No preview available - 2014 |
Common terms and phrases
acid actin activity apical arrowheads arrows associated axon basal blood bodies Capillary caused Cell Biol cellular central changes characteristic cisternae close collagen compartments complex components connective consists contain continuous cytoplasm dense disease domains electron endoplasmic reticulum endosomes endothelial enzymes epithelial epithelium extended fibres filaments formation function gene glycosylation Golgi apparatus granules hepatocytes human important intermediate involved labelling lamina layer leads lipid liver located lumen lysosomal matrix mechanism micrograph microscopy microtubule mitochondria molecular molecules multiple muscle mutations myosin nerve nuclear nucleus numerous observed occurs organelles organs outer panel particles pathway peroxisomes plasma membrane present processes proteins receptors References regions regulation represent response role Roth secretion secretory seen shown shows side smooth space specific stacks structure studies surface tion tissue traffic trans Golgi transport tubules ultrastructural vesicles visible